CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Complement factor D

Enzyme Information

3.4.21.79
Granzyme B.
based on mapping to UniProt P10144
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
-!- From cytotoxic T lymphocyte granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P10144
GRAB_HUMAN
Homo sapiens
Granzyme B

PDB Structure

PDB 1IAU
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.
Rotonda, J., Garcia-Calvo, M., Bull, H.G., Geissler, W.M., McKeever, B.M., Willoughby, C.A., Thornberry, N.A., Becker, J.W.
Chem.Biol.