CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Arsenate reductase

Enzyme Information

1.20.4.1
Arsenate reductase (glutaredoxin).
based on mapping to UniProt P08692
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.

UniProtKB Entries (1)

P08692
ARSC1_ECOLX
Escherichia coli
Arsenate reductase

PDB Structure

PDB 1I9D
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.
Martin, P., DeMel, S., Shi, J., Gladysheva, T., Gatti, D.L., Rosen, B.P., Edwards, B.F.
Structure