CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Alpha carbonic anhydrase 3

Enzyme Information
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 1I90
External Links
Organism Escherichia
Primary Citation
Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
Kim, C.Y., Whittington, D.A., Chang, J.S., Liao, J., May, J.A., Christianson, D.W.