CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.100
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q9KWU7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q9KWU6
RPOC_THEAQ
Thermus aquaticus
DNA-directed RNA polymerase subunit beta'

PDB Structure

PDB 1I6V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
Campbell, E.A., Korzheva, N., Mustaev, A., Murakami, K., Nair, S., Goldfarb, A., Darst, S.A.
Cell(Cambridge,Mass.)