CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 1I57
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Scapin, G., Patel, S., Patel, V., Kennedy, B., Asante-Appiah, E.
Protein Sci.