CATH Classification

CATH Clusters

Superfamily RNA polymerase ii
Functional Family DNA-directed RNA polymerase

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P16370
RPB3_YEAST
Saccharomyces cerevisiae S288c
DNA-directed RNA polymerase II subunit RPB3

PDB Structure

PDB 1I50
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.
Cramer, P., Bushnell, D.A., Kornberg, R.D.
Science