CATH Classification

Domain Context

CATH Clusters

Superfamily Electron Transport, Fmn-binding Protein; Chain A
Functional Family Ferric-chelate reductase (NAD(P)H)

Enzyme Information

1.16.1.10
Ferric-chelate reductase (NAD(P)H).
based on mapping to UniProt O29428
2 Fe(II)-siderophore + NAD(P)(+) + H(+) = 2 Fe(III)-siderophore + NAD(P)H.
-!- The enzyme catalyzes the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. -!- The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). -!- Cf. EC 1.16.1.7 and EC 1.16.1.9.

UniProtKB Entries (1)

O29428
FERCR_ARCFU
Archaeoglobus fulgidus DSM 4304
Ferric-chelate reductase (NAD(P)H)

PDB Structure

PDB 1I0S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+.
Chiu, H.J., Johnson, E., Schroder, I., Rees, D.C.
Structure