CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 1HX9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Single Active Site Mutations Change the Specificity of a Sesquiterpene Cyclase
Starks, C.S., Rising, K.A., Chappell, J., Noel, J.P.
To be Published