CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Cathepsin E

Enzyme Information

3.4.23.3
Gastricsin.
based on mapping to UniProt P20142
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
-!- Formed from progastricsin, apparently in the gastric juice of most vertebrates. -!- In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. -!- Seminal plasma contains a zymogen that is immunologically identical with progastricsin. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.22.

UniProtKB Entries (1)

P20142
PEPC_HUMAN
Homo sapiens
Gastricsin

PDB Structure

PDB 1HTR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal and molecular structures of human progastricsin at 1.62 A resolution.
Moore, S.A., Sielecki, A.R., Chernaia, M.M., Tarasova, N.I., James, M.N.
J.Mol.Biol.