CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine synthetase/guanido kinase, catalytic domain
Functional Family Glutamine synthetase

Enzyme Information

6.3.1.2
Glutamine synthetase.
based on mapping to UniProt P9WN39
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P9WN39
GLN1B_MYCTU
Mycobacterium tuberculosis H37Rv
Glutamine synthetase

PDB Structure

PDB 1HTQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Gill, H.S., Pfluegl, G.M., Eisenberg, D.
Biochemistry