CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.60
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q5SL87
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q5SL87
RUVB_THET8
Thermus thermophilus HB8
Holliday junction ATP-dependent DNA helicase RuvB

PDB Structure

PDB 1HQC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8.
Yamada, K., Kunishima, N., Mayanagi, K., Ohnishi, T., Nishino, T., Iwasaki, H., Shinagawa, H., Morikawa, K.
Proc.Natl.Acad.Sci.USA