1 keywords

CATH Domain 1hovA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.390 Collagenase (Catalytic Domain)
Homologous Superfamily 3.40.390.10 Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family

Enzyme Information

3.4.24.24
Gelatinase A.
based on mapping to UniProt P08253
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08253
MMP2_HUMAN
Homo sapiens
72 kDa type IV collagenase

PDB Structure

PDB 1HOV
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor
Feng, Y., Likos, J.J., Zhu, L., Woodward, H., Munie, G., McDonald, J.J., Stevens, A.M., Howard, C.P., De Crescenzo, G.A., Welsch, D., Shieh, H.-S., Stallings, W.C.
Biochim.Biophys.Acta