CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P28161
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P28161
GSTM2_HUMAN
Homo sapiens
Glutathione S-transferase Mu 2

PDB Structure

PDB 1HNA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity.
Raghunathan, S., Chandross, R.J., Kretsinger, R.H., Allison, T.J., Penington, C.J., Rule, G.S.
J.Mol.Biol.