CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P51900
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.22
Xanthine phosphoribosyltransferase.
based on mapping to UniProt P51900
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.

UniProtKB Entries (1)

P51900
HGXR_TRIFO
Tritrichomonas suis
Hypoxanthine-guanine-xanthine phosphoribosyltransferase

PDB Structure

PDB 1HGX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
Somoza, J.R., Chin, M.S., Focia, P.J., Wang, C.C., Fletterick, R.J.
Biochemistry