CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28509
HIR3_HIRME
Hirudo medicinalis
Hirudin-3

PDB Structure

PDB 1HDT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
Tabernero, L., Chang, C.Y., Ohringer, S.L., Lau, W.F., Iwanowicz, E.J., Han, W.C., Wang, T.C., Seiler, S.M., Roberts, D.G., Sack, J.S.
J.Mol.Biol.