CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28507
HIR3A_HIRME
Hirudo medicinalis
Hirudin-3A

PDB Structure

PDB 1HAH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Vijayalakshmi, J., Padmanabhan, K.P., Mann, K.G., Tulinsky, A.
Protein Sci.