CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P01050
HIRV1_HIRME
Hirudo medicinalis
Hirudin variant-1

PDB Structure

PDB 1H8I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
Skordalakes, E., Dodson, G.G., Green, D.S., Goodwin, C.A., Scully, M.F., Hudson, H.R., Kakkar, V.V., Deadman, J.J.
J.Mol.Biol.