CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1060 | Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2 |
|
1.10.1060.10 | Alpha-helical ferredoxin |
Domain Context
CATH Clusters
| Superfamily | Alpha-helical ferredoxin |
| Functional Family | Dihydropyrimidine dehydrogenase [NADP(+)] |
Enzyme Information
| 1.3.1.2 |
Dihydropyrimidine dehydrogenase (NADP(+)).
based on mapping to UniProt Q28943
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
-!- Also acts on dihydrothymine.
|
UniProtKB Entries (1)
| Q28943 |
DPYD_PIG
Sus scrofa
Dihydropyrimidine dehydrogenase [NADP(+)]
|
PDB Structure
| PDB | 1H7W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil.
EMBO J.
|