CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.360
Functional Family NAD(P)H dehydrogenase [quinone] 1

Enzyme Information

1.6.5.2
NAD(P)H dehydrogenase (quinone).
based on mapping to UniProt P15559
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P15559
NQO1_HUMAN
Homo sapiens
NAD(P)H dehydrogenase [quinone] 1

PDB Structure

PDB 1H66
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones
Faig, M., Bianchet, M.A., Winski, S., Hargreaves, R., Moody, C.J., Hudnott, A.R., Ross, D., Amzel, L.M.
Structure