CATH Classification

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA-directed RNA polymerase 3

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P00573
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P00573
RPOL_BPT7
Enterobacteria phage T7
T7 RNA polymerase

PDB Structure

PDB 1H38
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a T7 RNA Polymerase Elongation Complex at 2.9 A Resolution
Tahirov, T.H., Temiakov, D., Anikin, M., Patlan, V., Mcallister, W.T., Vassylyev, D.G., Yokoyama, S.
Nature