CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome-c3 Hydrogenase, chain B
Functional Family Hydrogenase 2 large subunit

Enzyme Information

1.12.2.1
Cytochrome-c3 hydrogenase.
based on mapping to UniProt P21852
H(2) + 2 ferricytochrome c3 = 2 H(+) + 2 ferrocytochrome c3.
-!- Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). -!- Methylene blue and other acceptors can also be reduced.

UniProtKB Entries (1)

P21852
PHNL_DESVM
Desulfovibrio vulgaris str. 'Miyazaki F'
Periplasmic [NiFe] hydrogenase large subunit

PDB Structure

PDB 1H2R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Removal of the bridging ligand atom at the Ni-Fe active site of [NiFe] hydrogenase upon reduction with H2, as revealed by X-ray structure analysis at 1.4 A resolution.
Higuchi, Y., Ogata, H., Miki, K., Yasuoka, N., Yagi, T.
Structure Fold.Des.