CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q01094
E2F1_HUMAN
Homo sapiens
Transcription factor E2F1

PDB Structure

PDB 1H24
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Lowe, E.D., Tews, I., Cheng, K.Y., Brown, N.R., Gul, S., Noble, M.E.M., Gamblin, S., Johnson, L.N.
Biochemistry