CATH Classification

Domain Context

CATH Clusters

Superfamily Carbohydrate-binding module superfamily 5/12
Functional Family

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P11797
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P11797
CHIB_SERMA
Serratia marcescens
Chitinase B

PDB Structure

PDB 1H0G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High Resolution Inhibited Complexes of a Chitinase with Natural Product Cyclopentapeptides - Peptide Mimicry of a Carbohydrate Substrate
Houston, D.R., Shiomi, K., Arai, N., Omura, S., Peter, M.G., Turberg, A., Synstad, B., Eijsink, V.G.H., Van Aalten, D.M.F.
Proc.Natl.Acad.Sci.USA