CATH Classification

Domain Context

CATH Clusters

Superfamily Hemopexin-like domain
Functional Family 72 kDa type IV collagenase

Enzyme Information

3.4.24.24
Gelatinase A.
based on mapping to UniProt P08253
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P16035
TIMP2_HUMAN
Homo sapiens
Metalloproteinase inhibitor 2

PDB Structure

PDB 1GXD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insight Into the Complex Formation of Latent Matrix Metalloproteinase 2 with Tissue Inhibitor of Metalloproteinase 2
Morgunova, E., Tuuttila, A., Bergmann, U., Tryggvason, K.
Proc.Natl.Acad.Sci.USA