CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase A4

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt O15217
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

O15217
GSTA4_HUMAN
Homo sapiens
Glutathione S-transferase A4

PDB Structure

PDB 1GUM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products
Bruns, C.M., Hubatsch, I., Ridderstrom, M., Mannervik, B., Tainer, J.A.
J.Mol.Biol.