CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (Central domain)
Functional Family Histidine ammonia-lyase

Enzyme Information

4.3.1.3
Histidine ammonia-lyase.
based on mapping to UniProt P21310
L-histidine = urocanate + NH(3).
-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25. -!- Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.

UniProtKB Entries (1)

P21310
HUTH_PSEPU
Pseudomonas putida
Histidine ammonia-lyase

PDB Structure

PDB 1GKM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Two Histidine Ammonia-Lyase Modifications and Implications for the Catalytic Mechanism
Baedeker, M., Schulz, G.E.
Eur.J.Biochem.