CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family

Enzyme Information

3.5.1.93
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt P07662
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.

UniProtKB Entries (1)

P07662
G7AC_PSEU7
Pseudomonas sp. SY-77-1
Glutaryl-7-aminocephalosporanic-acid acylase

PDB Structure

PDB 1GK0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Prediction of Modifications in Glutarylamidase to Allow Single-Step Enzymatic Production of 7-Aminocephalosporanic Acid from Cephalosporin C.
Fritz-Wolf, K., Koller, K., Lange, G., Liesum, A., Sauber, K., Schreuder, H., Aretz, W., Kabsch, W.
Protein Sci.