CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c-like domain
Functional Family Nitrite reductase

Enzyme Information
Hydroxylamine reductase.
based on mapping to UniProt P24474
NH(3) + H(2)O + acceptor = hydroxylamine + reduced acceptor.
-!- Reduced pyocyanine, methylene blue and flavins act as donors for the reduction of hydroxylamine. -!- May be identical to EC
Nitrite reductase (NO-forming).
based on mapping to UniProt P24474
Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+).
-!- The reaction is catalyzed by two types of enzymes, found in the perimplasm of denitrifying bacteria. -!- One type comprises proteins containing multiple copper centers, the other a heme protein, cytochrome cd1. -!- Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. -!- Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. -!- May also catalyze the reaction of EC since this is a well- known activity of cytochrome cd1. -!- Formerly EC, EC and EC

UniProtKB Entries (1)

Pseudomonas aeruginosa PAO1
Nitrite reductase

PDB Structure

External Links
Primary Citation
Cyanide Binding to Cd(1) Nitrite Reductase from Pseudomonas Aeruginosa: Role of the Active-Site His369 in Ligand Stabilization.
Sun, W., Arese, M., Brunori, M., Nurizzo, D., Brown, K., Cambillau, C., Tegoni, M., Cutruzzola, F.