CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.470 | Ricin (A Subunit), domain 2 |
|
4.10.470.10 | Ricin (A Subunit), domain 2 |
Domain Context
CATH Clusters
| Superfamily | Ricin (A Subunit), domain 2 |
| Functional Family |
Enzyme Information
| 3.2.2.22 |
rRNA N-glycosylase.
based on mapping to UniProt P09989
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
UniProtKB Entries (1)
| P09989 |
RIPT_TRIKI
Trichosanthes kirilowii
Ribosome-inactivating protein alpha-trichosanthin
|
PDB Structure
| PDB | 1GIS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants.
Protein Eng.
|