CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 1GII
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
Ikuta, M., Kamata, K., Fukasawa, K., Honma, T., Machida, T., Hirai, H., Suzuki-Takahashi, I., Hayama, T., Nishimura, S.
J.Biol.Chem.