CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator

PDB Structure

PDB 1GI8
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz, B.A., Elrod, K., Luong, C., Rice, M.J., Mackman, R.L., Sprengeler, P.A., Spencer, J., Hataye, J., Janc, J., Link, J., Litvak, J., Rai, R., Rice, K., Sideris, S., Verner, E., Young, W.
J.Mol.Biol.