CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1110.20
Functional Family

Enzyme Information

2.7.1.147
ADP-specific glucokinase.
based on mapping to UniProt Q7M537
ADP + D-glucose = AMP + D-glucose 6-phosphate.
-!- The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. -!- No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

UniProtKB Entries (1)

Q7M537
GLKA_THELN
Thermococcus litoralis DSM 5473
ADP-dependent glucokinase

PDB Structure

PDB 1GC5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis for the ADP-Specificity of a Novel Glucokinase from a Hyperthermophilic Archaeon
Ito, S., Fushinobu, S., Yoshioka, I., Koga, S., Matsuzawa, H., Wakagi, T.
Structure