CATH Domain 1g27B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.45	Peptide Deformylase
	3.90.45.10	Peptide deformylase

Domain Context

CATH Clusters

Superfamily	Peptide deformylase
Functional Family	Peptide deformylase

Enzyme Information

3.5.1.88

Peptide deformylase.

based on mapping to UniProt P0A6K3

Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.

-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

P0A6K3

DEF_ECOLI

Escherichia coli K-12

Peptide deformylase

PDB Structure

PDB	1G27
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor. Clements, J.M., Beckett, R.P., Brown, A., Catlin, G., Lobell, M., Palan, S., Thomas, W., Whittaker, M., Wood, S., Salama, S., Baker, P.J., Rodgers, H.F., Barynin, V., Rice, D.W., Hunter, M.G. Antimicrob.Agents Chemother.