CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Short-chain dehydrogenase reductase

Enzyme Information

1.1.1.252
Tetrahydroxynaphthalene reductase.
based on mapping to UniProt Q12634
Scytalone + NADP(+) = 1,3,6,8-tetrahydroxynaphthalene + NADPH.
-!- Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. -!- Involved with EC 4.2.1.94 in the biosynthesis of melanin in pathogenic fungi. -!- Formerly EC 1.3.1.50.

UniProtKB Entries (1)

Q12634
T4HR_MAGO7
Pyricularia oryzae 70-15
Tetrahydroxynaphthalene reductase

PDB Structure

PDB 1G0O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
Liao, D., Basarab, G.S., Gatenby, A.A., Valent, B., Jordan, D.B.
Structure