CATH Classification

Domain Context

CATH Clusters

Superfamily S15/NS1, RNA-binding
Functional Family bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15
Proline--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
6.1.1.17
Glutamate--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

UniProtKB Entries (1)

P07814
SYEP_HUMAN
Homo sapiens
Bifunctional glutamate/proline--tRNA ligase

PDB Structure

PDB 1FYJ
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats.
Jeong, E.J., Hwang, G.S., Kim, K.H., Kim, M.J., Kim, S., Kim, K.S.
Biochemistry