CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Histone acetyltransferase

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q08649
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q08649
ESA1_YEAST
Saccharomyces cerevisiae S288C
Histone acetyltransferase ESA1

PDB Structure

PDB 1FY7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases.
Yan, Y., Barlev, N.A., Haley, R.H., Berger, S.L., Marmorstein, R.
Mol.Cell