CATH Classification

Domain Context

CATH Clusters

Superfamily Exonuclease ExoI, domain 3
Functional Family Exodeoxyribonuclease I

Enzyme Information

3.1.11.1
Exodeoxyribonuclease I.
based on mapping to UniProt P04995
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.

UniProtKB Entries (1)

P04995
EX1_ECOLI
Escherichia coli K-12
Exodeoxyribonuclease I

PDB Structure

PDB 1FXX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Escherichia coli exonuclease I suggests how processivity is achieved.
Breyer, W.A., Matthews, B.W.
Nat.Struct.Biol.