CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-L-fucose synthase

Enzyme Information

1.1.1.271
GDP-L-fucose synthase.
based on mapping to UniProt P32055
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
-!- Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.

UniProtKB Entries (1)

P32055
FCL_ECOLI
Escherichia coli K-12
GDP-L-fucose synthase

PDB Structure

PDB 1FXS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Somers, W.S., Stahl, M.L., Sullivan, F.X.
Structure