CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P06244
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P06244
KAPA_YEAST
Saccharomyces cerevisiae S288C
CAMP-dependent protein kinase type 1

PDB Structure

PDB 1FOT
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structure of the unliganded cAMP-dependent protein kinase catalytic subunit from Saccharomyces cerevisiae.
Mashhoon, N., Carmel, G., Pflugrath, J.W., Kuret, J.
Arch.Biochem.Biophys.