CATH Classification

Domain Context

CATH Clusters

Superfamily 1.50.10.10
Functional Family alpha-1,2-Mannosidase

Enzyme Information

3.2.1.113
Mannosyl-oligosaccharide 1,2-alpha-mannosidase.
based on mapping to UniProt Q9UKM7
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
-!- Involved in the synthesis of glycoproteins.

UniProtKB Entries (1)

Q9UKM7
MA1B1_HUMAN
Homo sapiens
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

PDB Structure

PDB 1FMI
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
Vallee, F., Karaveg, K., Herscovics, A., Moremen, K.W., Howell, P.L.
J.Biol.Chem.