CATH Classification

Domain Context

CATH Clusters

Superfamily Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family TNF receptor-associated factor 6

Enzyme Information
RING-type E3 ubiquitin transferase.
based on mapping to UniProt Q13114
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Tumor necrosis factor receptor superfamily member 5

PDB Structure

External Links
Organism Escherichia
Primary Citation
Molecular basis for CD40 signaling mediated by TRAF3.
Ni, C.Z., Welsh, K., Leo, E., Chiou, C.K., Wu, H., Reed, J.C., Ely, K.R.