CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.50
3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
based on mapping to UniProt P80702
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on androsterone and other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. -!- Si-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.213).

UniProtKB Entries (1)

P80702
DIDH_COMTE
Comamonas testosteroni
3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase

PDB Structure

PDB 1FJH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.
Grimm, C., Maser, E., Mobus, E., Klebe, G., Reuter, K., Ficner, R.
J.Biol.Chem.