CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62937
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (2)

P62937
PPIA_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase A
P05889
GAG_HV1W2
Human immunodeficiency virus type 1 (WMJ2 ISOLATE)
Gag polyprotein

PDB Structure

PDB 1FGL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.
Zhao, Y., Chen, Y., Schutkowski, M., Fischer, G., Ke, H.
Structure