CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.40.20
Functional Family Formate dehydrogenase, alpha subunit

Enzyme Information

1.17.1.9
Formate dehydrogenase.
based on mapping to UniProt P07658
Formate + NAD(+) = CO(2) + NADH.
-!- The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center. -!- Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase. -!- Formerly EC 1.2.1.2.
1.17.99.7
Formate dehydrogenase (acceptor).
based on mapping to UniProt P07658
Formate + acceptor = CO(2) + reduced acceptor.
-!- Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. -!- The two enzymes form the formate-hydrogen lyase complex. -!- The enzyme contains a selenocysteine residue. -!- Formerly EC 1.1.99.33.

UniProtKB Entries (1)

P07658
FDHF_ECOLI
Escherichia coli K-12
Formate dehydrogenase H

PDB Structure

PDB 1FDI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.
Boyington, J.C., Gladyshev, V.N., Khangulov, S.V., Stadtman, T.C., Sun, P.D.
Science