CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family

Enzyme Information

3.4.21.102
C-terminal processing peptidase.
based on mapping to UniProt O04073
The enzyme shows specific recognition of a C-terminal tripeptide, Xaa- Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala- Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.
-!- In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II; this proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. -!- Belongs to peptidase family S41.

UniProtKB Entries (1)

O04073
CTPA_TETOB
Tetradesmus obliquus
C-terminal processing peptidase, chloroplastic

PDB Structure

PDB 1FC9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of the photosystem II D1 C-terminal processing protease.
Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B., Diner, B.A.
Nat.Struct.Biol.