CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family 5-aminolevulinate synthase, mitochondrial

Enzyme Information

2.3.1.29
Glycine C-acetyltransferase.
based on mapping to UniProt P0AB77
Acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate.
-!- Acts in concert with EC 1.1.1.103 in the degradation of threonine to form glycine. -!- This threonine degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex.

UniProtKB Entries (1)

P0AB77
KBL_ECOLI
Escherichia coli K-12
2-amino-3-ketobutyrate coenzyme A ligase

PDB Structure

PDB 1FC4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism.
Schmidt, A., Sivaraman, J., Li, Y., Larocque, R., Barbosa, J.A.R.G., Smith, C., Matte, A., Schrag, J.D., Cygler, M.
Biochemistry