CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor VII

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (2)

P00974
BPT1_BOVIN
Bos taurus
Pancreatic trypsin inhibitor
P13726
TF_HUMAN
Homo sapiens
Tissue factor

PDB Structure

PDB 1FAK
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.
Zhang, E., St Charles, R., Tulinsky, A.
J.Mol.Biol.