CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator

PDB Structure

PDB 1F5L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.
Zeslawska, E., Schweinitz, A., Karcher, A., Sondermann, P., Sperl, S., Sturzebecher, J., Jacob, U.
J.Mol.Biol.