CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | Squalene synthase |
Enzyme Information
| 2.5.1.21 |
Squalene synthase.
based on mapping to UniProt P37268
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
-!- This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols. -!- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. -!- When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). -!- High concentrations of FPP inhibit the production of squalene but not of PSPP.
|
UniProtKB Entries (1)
| P37268 |
FDFT_HUMAN
Homo sapiens
Squalene synthase
|
PDB Structure
| PDB | 1EZF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
J.Biol.Chem.
|