CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family palmitoyl-protein thioesterase 1

Enzyme Information

3.1.2.22
Palmitoyl-protein hydrolase.
based on mapping to UniProt P45478
Palmitoyl-[protein] + H(2)O = palmitate + [protein].
-!- Specific for long-chain thioesters of fatty acids. -!- Hydrolyzes fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.

UniProtKB Entries (1)

P45478
PPT1_BOVIN
Bos taurus
Palmitoyl-protein thioesterase 1

PDB Structure

PDB 1EXW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.
Das, A.K., Bellizzi III, J.J., Tandel, S., Biehl, E., Clardy, J., Hofmann, S.L.
J.Biol.Chem.